US states by drug overdose deaths (12 months)
California had the highest drug overdose deaths (12 months) of 51 states in September 2025, at 9,198. Wyoming had the lowest, at 83. The median was 1,000 and the figure for the United States was 71,892. Source: Centers for Disease Control and Prevention.
All states, September 2025
Full ranking
| Rank | States | September 2025 | Change on September 2024 |
|---|---|---|---|
| 1 | California Provisional | 9,198 | -10.6% |
| 2 | Texas Provisional | 4,415 | -15.8% |
| 3 | Florida Provisional | 4,074 | -30.3% |
| 4 | New York Provisional | 3,807 | -27.3% |
| 5 | Washington Provisional | 3,159 | -2.6% |
| 6 | Pennsylvania Provisional | 2,973 | -19.4% |
| 7 | Arizona Provisional | 2,914 | +18.4% |
| 8 | Ohio Provisional | 2,518 | -28.4% |
| 9 | North Carolina Provisional | 2,472 | -9.8% |
| 10 | Tennessee Provisional | 2,238 | -21.4% |
| 11 | Illinois Provisional | 2,051 | -27.2% |
| 12 | Colorado Provisional | 1,780 | +3.7% |
| 13 | Georgia Provisional | 1,714 | -20% |
| 14 | Michigan Provisional | 1,706 | -22.2% |
| 15 | New Jersey Provisional | 1,661 | -21.6% |
| 16 | Indiana Provisional | 1,488 | -18.2% |
| 17 | Maryland Provisional | 1,403 | -31.2% |
| 18 | South Carolina Provisional | 1,348 | -17.8% |
| 19 | Oregon Provisional | 1,339 | -18.4% |
| 20 | Massachusetts Provisional | 1,335 | -25.9% |
| 21 | Virginia Provisional | 1,313 | -24.9% |
| 22 | Kentucky Provisional | 1,286 | -23.3% |
| 23 | Missouri Provisional | 1,280 | -21.2% |
| 24 | Nevada Provisional | 1,249 | -17.8% |
| 25 | Louisiana Provisional | 1,207 | -29.4% |
| 26 | Minnesota Provisional | 1,000 | -9.2% |
| 27 | Wisconsin Provisional | 957 | -27.2% |
| 28 | Alabama Provisional | 926 | -28.5% |
| 29 | New Mexico Provisional | 907 | +9.9% |
| 30 | Oklahoma Provisional | 906 | -16.8% |
| 31 | Connecticut Provisional | 896 | -16.1% |
| 32 | West Virginia Provisional | 682 | -30.1% |
| 33 | Utah Provisional | 677 | -7.3% |
| 34 | Kansas Provisional | 559 | 0% |
| 35 | Mississippi Provisional | 468 | -14.6% |
| 36 | Iowa Provisional | 408 | +0.5% |
| 37 | Maine Provisional | 391 | -23.6% |
| 38 | Arkansas Provisional | 371 | -8.8% |
| 39 | Delaware Provisional | 338 | -12.9% |
| 40 | Alaska Provisional | 331 | -12.4% |
| 41 | District of Columbia Provisional | 325 | -32.4% |
| 42 | Hawaii Provisional | 309 | -3.7% |
| 43 | Idaho Provisional | 286 | -18.8% |
| 44 | New Hampshire Provisional | 251 | -20.3% |
| 45 | Rhode Island Provisional | 227 | -40.6% |
| 46 | Montana Provisional | 178 | -3.3% |
| 47 | Nebraska Provisional | 138 | -7.4% |
| 47 | Vermont Provisional | 138 | -38.4% |
| 49 | North Dakota Provisional | 129 | +5.7% |
| 50 | South Dakota Provisional | 83 | -3.5% |
| 50 | Wyoming Provisional | 83 | -29.1% |
Other periods
About this ranking
Drug overdose deaths that occurred in the area during the 12 months ending in the month shown. The value for March 2026 covers April 2025 through March 2026. Underlying cause of death coded X40 to X44, X60 to X64, X85 or Y10 to Y14 (ICD-10).
United States: CDC National Vital Statistics System provisional counts, as reported, not the predicted counts CDC also publishes. Recent months are incomplete and usually rise as death records arrive; periods without final data are marked provisional. Deaths are counted where they occurred. The national figure covers the 50 states and DC. CDC publishes New York City separately; the New York State value is the sum of New York City and the rest of the state. Consecutive months overlap by 11 months, so they must not be added together.
Every value in the ranking comes from the same publisher and the same period, so the states are compared on one definition. Equal values share a rank.
How to cite
Centers for Disease Control and Prevention (CDC). VSRR Provisional Drug Overdose Death Counts (xkb8-kh2a), reported number of drug overdose deaths, 12 month-ending. https://data.cdc.gov/resource/xkb8-kh2a.json?%24order=%3Aid&%24limit=50000&%24where=indicator%3D%27Number+of+Drug+Overdose+Deaths%27+AND+period%3D%2712+month-ending%27. Retrieved 2026-10-09.
Use this data in your AI agent
Invokely serves this figure to AI assistants through MCP and to code through a REST API, with the source and citation attached. Ask your assistant:
Rank US states by drug overdose deaths (12 months) using official data, and cite the source.
rank_places {"indicator":"drug_overdose_deaths_12m","level":"region","within":"United States","limit":10}
GET https://invokely.ai/api/v1/rank?indicator=drug_overdose_deaths_12m&level=region&within=United%20States&limit=10
Questions
Which state has the highest drug overdose deaths (12 months)?
California, with 9,198 in September 2025, according to Centers for Disease Control and Prevention.
Which state has the lowest drug overdose deaths (12 months)?
Wyoming, with 83 in September 2025.
Where does this ranking come from?
Every value comes from one source and one period, so the places are comparable: Centers for Disease Control and Prevention, VSRR Provisional Drug Overdose Death Counts (xkb8-kh2a), reported number of drug overdose deaths, 12 month-ending. Retrieved 2026-10-09.
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