Data / Rankings / Depression in adults, local model estimate / Cities in South Carolina

Cities in South Carolina by depression in adults, local model estimate, 2023

Clemson, SC had the highest depression in adults, local model estimate of 43 cities in 2023, at 27%. Hilton Head Island, SC had the lowest, at 16.8%. The median was 22.5%. Source: the Centers for Disease Control and Prevention.

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Highest27Clemson, SC
Lowest16.8Hilton Head Island, SC
Median22.543 cities

All cities, 2023

Clemson, SC: 27 %Clemson, SC27Cayce, SC: 25.7 %Cayce, SC25.7Anderson, SC: 25.6 %Anderson, SC25.6Columbia, SC: 25.2 %Columbia, SC25.2Conway, SC: 24.1 %Conway, SC24.1Easley, SC: 24.1 %Easley, SC24.1West Columbia, SC: 24.1 %West Columbia, SC24.1Greenwood, SC: 24 %Greenwood, SC24Lexington, SC: 23.8 %Lexington, SC23.8Spartanburg, SC: 23.8 %Spartanburg, SC23.8Hanahan, SC: 23.1 %Hanahan, SC23.1Moncks Corner, SC: 22.9 %Moncks Corner, SC22.9North Augusta, SC: 22.9 %North Augusta, SC22.9Goose Creek, SC: 22.8 %Goose Creek, SC22.8Irmo, SC: 22.8 %Irmo, SC22.8Summerville, SC: 22.8 %Summerville, SC22.8York, SC: 22.8 %York, SC22.8Forest Acres, SC: 22.7 %Forest Acres, SC22.7Charleston, SC: 22.6 %Charleston, SC22.6Greer, SC: 22.6 %Greer, SC22.6Newberry, SC: 22.6 %Newberry, SC22.6Fountain Inn, SC: 22.5 %Fountain Inn, SC22.5Gaffney, SC: 22.4 %Gaffney, SC22.4Greenville, SC: 22.4 %Greenville, SC22.4Florence, SC: 22.3 %Florence, SC22.3Rock Hill, SC: 22.2 %Rock Hill, SC22.2Fort Mill, SC: 22 %Fort Mill, SC22Simpsonville, SC: 21.8 %Simpsonville, SC21.8Myrtle Beach, SC: 21.6 %Myrtle Beach, SC21.6Aiken, SC: 21.5 %Aiken, SC21.5North Charleston, SC: 21.5 %North Charleston, SC21.5Mount Pleasant, SC: 21.4 %Mount Pleasant, SC21.4Orangeburg, SC: 21.4 %Orangeburg, SC21.4Mauldin, SC: 21.3 %Mauldin, SC21.3Sumter, SC: 21.1 %Sumter, SC21.1James Island, SC: 20.9 %James Island, SC20.9Tega Cay, SC: 20.6 %Tega Cay, SC20.6Hardeeville, SC: 20.5 %Hardeeville, SC20.5Port Royal, SC: 20.4 %Port Royal, SC20.4Beaufort, SC: 19.7 %Beaufort, SC19.7North Myrtle Beach, SC: 19.6 %North Myrtle Beach, SC19.6Bluffton, SC: 19.1 %Bluffton, SC19.1Hilton Head Island, SC: 16.8 %Hilton Head Island, SC16.8Clemson, SC: 27 %Clemson, SC27Cayce, SC: 25.7 %Cayce, SC25.7Anderson, SC: 25.6 %Anderson, SC25.6Columbia, SC: 25.2 %Columbia, SC25.2Conway, SC: 24.1 %Conway, SC24.1Easley, SC: 24.1 %Easley, SC24.1West Columbia, SC: 24.1 %West Columbia, SC24.1Greenwood, SC: 24 %Greenwood, SC24Lexington, SC: 23.8 %Lexington, SC23.8Spartanburg, SC: 23.8 %Spartanburg, SC23.8Hanahan, SC: 23.1 %Hanahan, SC23.1Moncks Corner, SC: 22.9 %Moncks Corner, SC22.9North Augusta, SC: 22.9 %North Augusta, SC22.9Goose Creek, SC: 22.8 %Goose Creek, SC22.8Irmo, SC: 22.8 %Irmo, SC22.8Summerville, SC: 22.8 %Summerville, SC22.8York, SC: 22.8 %York, SC22.8Forest Acres, SC: 22.7 %Forest Acres, SC22.7Charleston, SC: 22.6 %Charleston, SC22.6Greer, SC: 22.6 %Greer, SC22.6Newberry, SC: 22.6 %Newberry, SC22.6Fountain Inn, SC: 22.5 %Fountain Inn, SC22.5Gaffney, SC: 22.4 %Gaffney, SC22.4Greenville, SC: 22.4 %Greenville, SC22.4Florence, SC: 22.3 %Florence, SC22.3Rock Hill, SC: 22.2 %Rock Hill, SC22.2Fort Mill, SC: 22 %Fort Mill, SC22Simpsonville, SC: 21.8 %Simpsonville, SC21.8Myrtle Beach, SC: 21.6 %Myrtle Beach, SC21.6Aiken, SC: 21.5 %Aiken, SC21.5North Charleston, SC: 21.5 %North Charleston, SC21.5Mount Pleasant, SC: 21.4 %Mount Pleasant, SC21.4Orangeburg, SC: 21.4 %Orangeburg, SC21.4Mauldin, SC: 21.3 %Mauldin, SC21.3Sumter, SC: 21.1 %Sumter, SC21.1James Island, SC: 20.9 %James Island, SC20.9Tega Cay, SC: 20.6 %Tega Cay, SC20.6Hardeeville, SC: 20.5 %Hardeeville, SC20.5Port Royal, SC: 20.4 %Port Royal, SC20.4Beaufort, SC: 19.7 %Beaufort, SC19.7North Myrtle Beach, SC: 19.6 %North Myrtle Beach, SC19.6Bluffton, SC: 19.1 %Bluffton, SC19.1Hilton Head Island, SC: 16.8 %Hilton Head Island, SC16.8
%. Source: CDC, PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence. Retrieved 2026-10-12.

Full ranking

RankCities2023 (%)Change on 2022
1Clemson, SC27+1.1 pts
2Cayce, SC25.7+4.1 pts
3Anderson, SC25.6+1.5 pts
4Columbia, SC25.2+2.5 pts
5Conway, SC24.1+0.6 pts
5Easley, SC24.1+1.8 pts
5West Columbia, SC24.1+3.9 pts
8Greenwood, SC24+0.5 pts
9Lexington, SC23.8+4.5 pts
9Spartanburg, SC23.8-0.1 pts
11Hanahan, SC23.1+0.4 pts
12Moncks Corner, SC22.9+0.6 pts
12North Augusta, SC22.9+1.8 pts
14Goose Creek, SC22.8+0.4 pts
14Irmo, SC22.8+2.6 pts
14Summerville, SC22.8+0.8 pts
14York, SC22.8+2.5 pts
18Forest Acres, SC22.7+2.2 pts
19Charleston, SC22.6+0.9 pts
19Greer, SC22.6-0.6 pts
19Newberry, SC22.6+1 pts
22Fountain Inn, SC22.5-0.2 pts
23Gaffney, SC22.4+1 pts
23Greenville, SC22.4-0.3 pts
25Florence, SC22.3+2.6 pts
26Rock Hill, SC22.2+2.4 pts
27Fort Mill, SC22+2.5 pts
28Simpsonville, SC21.8-0.6 pts
29Myrtle Beach, SC21.6+0.5 pts
30Aiken, SC21.5+1.9 pts
30North Charleston, SC21.5+0.6 pts
32Mount Pleasant, SC21.4+0.9 pts
32Orangeburg, SC21.4+2.2 pts
34Mauldin, SC21.3-0.4 pts
35Sumter, SC21.1+0.1 pts
36James Island, SC20.9+1.2 pts
37Tega Cay, SC20.6+2.1 pts
38Hardeeville, SC20.5+0.7 pts
39Port Royal, SC20.4-0.3 pts
40Beaufort, SC19.7+0.6 pts
41North Myrtle Beach, SC19.6+0.6 pts
42Bluffton, SC19.1-0.6 pts
43Hilton Head Island, SC16.8+0.1 pts

Other periods

About this ranking

Percentage of adults who have ever been told by a doctor, nurse or other health professional that they had a depressive disorder. Model-based estimate for adults aged 18 and over from CDC PLACES. Crude prevalence, not age-adjusted.

US counties and cities (incorporated places of 10,000 or more). CDC PLACES combines Behavioral Risk Factor Surveillance System (BRFSS) answers with local population data through multilevel regression and poststratification, so a county or city value is a model estimate, not a survey count. The year is the BRFSS survey year, not the release year. CDC says the method does not support tracking change in a place over time, and each annual release can change the model, so values for different years are not strictly comparable. A state is missing in a year when its BRFSS data did not meet standards (Kentucky and Pennsylvania in 2023, Florida in 2021). Connecticut counties appear as its nine planning regions from 2022; its eight former counties are not served. City values for 2021 come from the 2023 release, built on 2010 Census place boundaries; later years use 2020 boundaries.

Every value in the ranking comes from the same publisher and the same period, so the cities are compared on one definition. Equal values share a rank.

How to cite

Centers for Disease Control and Prevention (CDC). PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence. https://www.cdc.gov/places/. Retrieved 2026-10-12. These data are available free from CDC. Use does not imply endorsement by CDC, ATSDR, HHS or the United States Government.

Citation styles

The publisher is the author. Invokely is named only as the place the figures were read, where a style asks for it.

APA 7

Centers for Disease Control and Prevention. (2025). PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence (Cities in South Carolina by depression in adults, local model estimate, 2023) [Data set]. Retrieved October 12, 2026, from https://www.cdc.gov/places/

MLA 9

PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence, Cities in South Carolina by depression in adults, local model estimate, 2023. Centers for Disease Control and Prevention, 12 Dec. 2025, https://www.cdc.gov/places/. Invokely, https://invokely.ai/rankings/adult-depression-rate-county-estimate/south-carolina-cities. Accessed 12 Oct. 2026.

Chicago (author-date)

Centers for Disease Control and Prevention. 2025. PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence. Cities in South Carolina by depression in adults, local model estimate, 2023. Dataset. Accessed October 12, 2026. https://www.cdc.gov/places/. Also distributed by Invokely, https://invokely.ai/rankings/adult-depression-rate-county-estimate/south-carolina-cities.

Harvard

Centers for Disease Control and Prevention (2025) PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence, Cities in South Carolina by depression in adults, local model estimate, 2023 [Dataset]. Available at: https://www.cdc.gov/places/, via Invokely: https://invokely.ai/rankings/adult-depression-rate-county-estimate/south-carolina-cities (Accessed: 12 October 2026).

BibTeX
@misc{centers_cities_in_south_carolina_2023,
  author = {{Centers for Disease Control and Prevention}},
  title = {{PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence: Cities in South Carolina by depression in adults, local model estimate, 2023}},
  year = {2025},
  howpublished = {Data set},
  url = {https://www.cdc.gov/places/},
  urldate = {2026-10-12},
  note = {Accessed via Invokely, https://invokely.ai/rankings/adult-depression-rate-county-estimate/south-carolina-cities. Publisher attribution: Centers for Disease Control and Prevention (CDC). PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence. https://www.cdc.gov/places/. Retrieved 2026-10-12. These data are available free from CDC. Use does not imply endorsement by CDC, ATSDR, HHS or the United States Government.},
}
RIS
TY  - DATA
AU  - Centers for Disease Control and Prevention
TI  - PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence: Cities in South Carolina by depression in adults, local model estimate, 2023
PY  - 2025
DA  - 2025/12/12
PB  - Centers for Disease Control and Prevention
DB  - Invokely
UR  - https://www.cdc.gov/places/
L2  - https://invokely.ai/rankings/adult-depression-rate-county-estimate/south-carolina-cities
Y2  - 2026/10/12
N1  - Accessed via Invokely, https://invokely.ai/rankings/adult-depression-rate-county-estimate/south-carolina-cities.
N1  - Publisher attribution: Centers for Disease Control and Prevention (CDC). PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence. https://www.cdc.gov/places/. Retrieved 2026-10-12. These data are available free from CDC. Use does not imply endorsement by CDC, ATSDR, HHS or the United States Government.
ER  -
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Rank Cities in South Carolina by depression in adults, local model estimate using official data, and cite the source.
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Questions

Which city has the highest depression in adults, local model estimate?

Clemson, SC, with 27% in 2023, according to the Centers for Disease Control and Prevention.

Which city has the lowest depression in adults, local model estimate?

Hilton Head Island, SC, with 16.8% in 2023.

Where does this ranking come from?

Every value comes from one source and one period, so the places are comparable: Centers for Disease Control and Prevention, PLACES: Local Data for Better Health, Place Data (eav7-hnsx, sd8v-uq83, krqc-563j and later releases), depression in adults, crude prevalence. Retrieved 2026-10-12.

Depression in adults, local model estimate: other rankings

Cities in South Carolina: more rankings